Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one-third of the cases – 19 million people.  Recent findings indicate that non-invasive brain transcranial current stimulation (tCS/tES) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects.

During my time at Neuroelectrics, I worked in this project where our ambition was to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields.

Galvani’s vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The inflection point is to prevent epileptic seizures from a bottom-up mechanistic understanding and control of tCS effects. This will entail a paradigm shift in epileptic disorders and beyond.

Our research strategy seeks to: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders.

Check the project’s website for more information.

Laura Dubreuil Vall
Laura Dubreuil Vall
Engineer and Neuroscientist

My research interests include neurotechnology, electroencephalography, brain stimulation, machine learning, product development and healthcare strategy.