Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one-third of the cases – 19 million people. Recent findings indicate that non-invasive brain transcranial current stimulation (tCS/tES) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects.
During my time at Neuroelectrics, I worked in this project where our ambition was to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields.
Galvani’s vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The inflection point is to prevent epileptic seizures from a bottom-up mechanistic understanding and control of tCS effects. This will entail a paradigm shift in epileptic disorders and beyond.
Our research strategy seeks to: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders.
Check the project’s website for more information.
- Personalized, Multisession, Multichannel Transcranial Direct Current Stimulation in Medication-Refractory Focal Epilepsy: An Open-Label Study
- Transcranial Direct Current Stimulation Modulates Dysexecutive Deficits and its Neurophysiological Signatures in Attention-Deficit Hyperactivity Disorder
- Transcranial Direct Current Stimulation to the Left Dorsolateral Prefrontal Cortex Improves Cognitive Control in Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Behavioral and Neurophysiological Study
- The effects of transcranial direct current stimulation in chronic spinal cord injury: a quantitative EEG study
- EEG Recordings During Sham Control Transcranial Direct Current Stimulation Protocol